要么重写这个控件的 OnPaint 事件，判断 BorderStyle 属性为 FixedSingle 的时候自绘其他颜色。
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要么不重写，把 BorderStyle 设为 None，直接在这个控件的 Paint 事件里自绘边框，例如：
Private Sub Label1_Paint(sender As Object, e As PaintEventArgs) Handles Label1.Paint
e.Graphics.DrawRectangle(Pens.Red, New Rectangle(Label1.DisplayRectangle.X, Label1.DisplayRectangle.Y, Label1.DisplayRectangle.Width - 1, Label1.DisplayRectangle.Height - 1))
End Sub
运行效果：
这是随机变的，你可以把过程写在Timer控件里，就自动变了。
Option
Explicit
Private
Sub
Form_click()
BackColor
=
RGB(0,
255,
0)
Width
=
8000
Height
=
8000
Randomize
Cls
Me.ForeColor
=
RGB(Rnd
*
255,
Rnd
*
255,
Rnd
*
255)
Call
drawcircle(ScaleWidth
/
2,
ScaleHeight
/
2,
ScaleWidth
/
6.5)
End
Sub
Private
Sub
drawcircle(x
As
Integer,
y
As
Integer,
r
As
Integer)
Dim
i
As
Integer
If
r
60
Then
Circle
(x,
y),
r
Else
Circle
(x,
y),
r
For
i
=
To
7
Call
drawcircle(x
+
2
*
r
*
Cos(i
*
3.141593
/
4),
y
+
2
*
r
*
Sin(i
*
3.141593
/
4),
r
/
3.5)
Next
i
End
If
End
Sub
要用GreateGrahpics函数，比如要向 Panel1，填充颜色：
Dim g As Graphic=Panel1.CreateGraphics
Dim b as New Brush(Color.Blue)
g.FillRectangle(b,Panel1)
写的比较粗，意思就是这样的，你可以边看帮助边细细完成
Private Sub Command1_MouseDown(Button As Integer, Shift As Integer, X As Single, Y As Single)
form1.backcolor = vbRed
endsub
Private Sub Command1_MouseUp(Button As Integer, Shift As Integer, X As Single, Y As Single)
form1.backcolor = vbGreen
end sub
扩展资料：
VB当中的颜色代码
vbBlack H0 黑色
vbRed HFF 红色
vbGreen HFF00 绿色
vbYellow HFFFF 黄色
vbBlue HFF0000 兰色
vbMagenta HFF00FF 洋红
vbCyan HFFFF00 青色
vbWhite HFFFFFF 白色
vbGrayText H80000011 变灰的（无效的）文字
vbButtonText H80000012 揿压按钮上文字的颜色
vbInactiveCaptionText H80000013 非活动标题内文字的颜色
vb3DHighlight H80000014 三维显示元素的高亮颜色
vb3DDKShadow H80000015 三维显示元素的最暗阴影颜色
vb3DLight H80000016 低于 vb3Dhighlight 的 三维次高亮颜色
vb3DFace H8000000F 文字表面的颜色
vb3DShadow H80000010 文字阴影的颜色
vbInfoText H80000017 提示窗内文字的颜色
vbInfoBackground H80000018 提示窗内背景的颜色
这篇文章介绍了VB.NET设置屏幕分辨率、颜色位数、刷新率
实例代码，有需要的朋友可以参考一下
复制代码
代码如下:
Private
Declare
Function
GetDeviceCaps
Lib
"gdi32"
(ByVal
hdc
As
Long,
ByVal
nIndex
As
Long)
As
Long
Private
Declare
Function
ChangeDisplaySettings
Lib
"user32"
Alias
"ChangeDisplaySettingsA"
(lpDevMode
As
Any,
ByVal
dwflags
As
Long)
As
Long
Private
Const
CCDEVICENAME
As
Long
=
32
Private
Const
CCFORMNAME
As
Long
=
32
Private
Const
DM_BITSPERPEL
As
Long
=
H40000
Private
Const
DM_PELSWIDTH
As
Long
=
H80000
Private
Const
DM_PELSHEIGHT
As
Long
=
H100000
Private
Const
DM_DISPLAYFLAGS
As
Long
=
H200000
Private
Const
DM_DISPLAYFREQUENCY
=
H400000
Private
Const
CDS_FORCE
As
Long
=
H80000000
Private
Const
BITSPIXEL
As
Long
=
12
Private
Const
HORZRES
As
Long
=
8
Private
Const
VERTRES
As
Long
=
10
Private
Const
VREFRESH
=
116
Private
Type
DEVMODE
dmDeviceName
As
String
*
CCDEVICENAME
dmSpecVersion
As
Integer
dmDriverVersion
As
Integer
dmSize
As
Integer
dmDriverExtra
As
Integer
dmFields
As
Long
dmOrientation
As
Integer
dmPaperSize
As
Integer
dmPaperLength
As
Integer
dmPaperWidth
As
Integer
dmScale
As
Integer
dmCopies
As
Integer
dmDefaultSource
As
Integer
dmPrintQuality
As
Integer
dmColor
As
Integer
dmDuplex
As
Integer
dmYResolution
As
Integer
dmTTOption
As
Integer
dmCollate
As
Integer
dmFormName
As
String
*
CCFORMNAME
dmUnusedPadding
As
Integer
dmBitsPerPel
As
Integer
dmPelsWidth
As
Long
dmPelsHeight
As
Long
dmDisplayFlags
As
Long
dmDisplayFrequency
As
Long
End
Type
Private
Sub
cmdChangeDesktopMode_Click()
Dim
DM
As
DEVMODE
With
DM
.dmPelsWidth
=
CInt(txtNewWidth.Text)
.dmPelsHeight
=
CInt(txtNewHeight.Text)
.dmBitsPerPel
=
CInt(txtNewColor.Text)
.dmDisplayFrequency
=
CInt(txtNewFreq.Text)
.dmFields
=
DM_PELSWIDTH
Or
DM_PELSHEIGHT
Or
DM_BITSPERPEL
Or
DM_DISPLAYFREQUENCY
.dmSize
=
LenB(DM)
End
With
If
ChangeDisplaySettings(DM,
CDS_FORCE)
Then
MsgBox
"错误!不支持此模式！"
End
If
End
Sub
Private
Sub
Form_Load()
txtOldWidth.Text
=
GetDeviceCaps(Me.hdc,
HORZRES)
txtOldHeight.Text
=
GetDeviceCaps(Me.hdc,
VERTRES)
txtOldColor.Text
=
GetDeviceCaps(Me.hdc,
BITSPIXEL)
txtOldFreq.Text
=
GetDeviceCaps(Me.hdc,
VREFRESH)
End
Sub
绘制线条采用Draw开头的方法，颜色参数用Pen类；
绘制有填充色的封闭图形采用Fill开头的方法，颜色参数用Brush类；
例如：
'绘制一个实心圆，该圆在：直线x=200，y=200，x=200+100，y=200+100所划矩形区域内
Me.CreateGraphics.FillEllipse(New SolidBrush(Color.Orange), 200, 200, 100, 100)
'绘制一个空心圆，该圆在：直线x=200，y=200，x=200+100，y=200+100所划矩形区域内
Me.CreateGraphics.DrawEllipse(New Pen(Color.Black), 200, 200, 100, 100)
