'vb全局快捷键是个大大滴难题，不好整。以下是个演示，办法比较笨，本人自用的，你试试。
我们提供的服务有：成都做网站、成都网站设计、微信公众号开发、网站优化、网站认证、六盘水ssl等。为1000多家企事业单位解决了网站和推广的问题。提供周到的售前咨询和贴心的售后服务，是有科学管理、有技术的六盘水网站制作公司
'窗体放上控件：Command1、Label1、Check1、Check2、Text1、Text2、Timer1
'加入以下代码，运行，设置"确定"键的快捷键
'可选"CTRL+某键"或者"SHIFT+某键"
'"某键"自己设置，只能设置为字母或数字
Private Declare Function GetAsyncKeyState Lib "user32" _
(ByVal vKey As Long) As Integer 'API声明
Dim i
'================================================================
'这部分是设置各控件的大小、位置和初始属性，为了便于演示才加的，
'你可以自行设计好各控件的大小、位置和初始属性，无需这些代码。
Private Sub Form_Load()
Form1.Width = 2690: Form1.Height = 2100
Command1.Width = 1215: Command1.Height = 495
Command1.Top = 120: Command1.Left = 120
Command1.Caption = "确定"
Label1.Width = 2175: Label1.Height = 255
Label1.Top = 720: Label1.Left = 120
Label1.Caption = "设置 确定 键的快捷键："
Check1.Width = 975: Check1.Height = 255
Check1.Top = 960: Check1.Left = 120
Check1.Caption = "CTRL +"
Check2.Width = 975: Check2.Height = 255
Check2.Top = 1320: Check2.Left = 120
Check2.Caption = "SHIFT +"
Text1.Width = 255: Text1.Height = 270
Text1.Top = 960: Text1.Left = 1080
Text1.Text = ""
Text2.Width = 255: Text2.Height = 270
Text2.Top = 1320: Text2.Left = 1080
Text2.Text = ""
Timer1.Interval = 10 'Timer的属性，必须设置
End Sub
'以上部分是设置各控件的大小、位置和初始属性，为了便于演示才加的，
'你可以自行设计好各控件的大小、位置和初始属性，无需这些代码。
'================================================================
Private Sub Timer1_Timer()
If Text1 "" Then
If Len(Text1) 1 Then Text1 = Left(Text1, 1)
If Asc("a") = Asc(Text1) And Asc(Text1) = Asc("z") _
Then Text1 = Chr(Asc(Text1) - 32)
If Check1.Value = 1 And GetAsyncKeyState(vbKeyControl) 0 _
And GetAsyncKeyState(Asc(Text1)) 0 Then
i = i + 1
If i = 1 Then Call Command1_Click
Else
i = 0
End If
End If
If Text2 "" Then
If Len(Text2) 1 Then Text2 = Left(Text2, 1)
If Asc("a") = Asc(Text2) And Asc(Text2) = Asc("z") _
Then Text2 = Chr(Asc(Text2) - 32)
If Check2.Value = 1 And GetAsyncKeyState(vbKeyShift) 0 _
And GetAsyncKeyState(Asc(Text2)) 0 Then
i = i + 1
If i = 1 Then Call Command1_Click
Else
i = 0
End If
End If
End Sub
Private Sub Command1_Click()
print "你好"
SendKeys "你好"
End Sub
新建一个Form1把Form1的KeyPreview改成True
拖入一个Button1到Form1上面
然后加入以下代码
Private Sub Form1_KeyDown(sender As Object, e As KeyEventArgs) Handles Me.KeyDown
If e.KeyData = (Keys.Alt Or Keys.G) Then
Button1.PerformClick() '或者用Button1_Click(Nothing, New EventArgs)
'快捷键Alt+G触发Button1_Click()事件。
End If
End Sub
Private Sub Button1_Click(sender As Object, e As EventArgs) Handles Button1.Click
Button1.Size = New Size(180, 23)
Button1.Text = "我被局部快捷键给召唤了~"
End Sub
很正常嘛，如果项目下还有子菜单项话，是无效的，必须是最底层菜单项。
VB.NET即时窗口用于在设计时调试和计算表达式、执行语句、输出变量值等
快捷键是：CTRL+G 或者按 CTRL+ALT+I
